Research Studies with LEGEND® Injectable solution
Effects of Intravenous Administration of Sodium Hyaluronate on Carpal Joints in Exercise in Horses after Arthroscopic Surgery in Osteochondral Fragmentation.1
Materials and Methods
A study was completed by the Colorado State Equine orthopedic group in twelve clinically sound horses with normal radiographic appearance of their carpal joints. On day 0 each horse had arthroscopic examinations of each carpal joint. One joint in each horse was randomly selected and an osteochondral fragment or bone chip was created with in that joint. Synovial fluid samples were taken on days 0, 13, 20, 27, 34, and 72. Six horses were treated with 40 mg IV LEGEND and six were treated with IV saline on days 13, 20, and 27. Note that the last synovial fluid sample was taken 45 days after the last treatment.
All horses were exercised on a treadmill 5 days a week starting at day 15 which was two days after the first treatment with LEGEND. The study ended on day 72.
Clinical examination, synovial fluid analysis and microscopic examination revealed that the IV administration of LEGEND:
- Deceased the degree of lameness
- Decreased the synovial fluid PGE2 levels
- Decreased synovial fluid protein levels
- Decreased synovial membrane cellularity
- Decreased the synovial membrane vascularity
Field Studies with LEGEND (hyaluronate sodium) Injectable Solution2
Field studies were conducted at four different equine veterinary hospitals in the US.
Twenty-one horses were treated with IV LEGEND and twenty-five horses were treated with IA LEGEND. The horses had either carpal or fetlock joint lameness and received 1-3 injections based on clinical improvement.
Overall clinical improvement judged as excellent to good in:
- 90% of cases treated with IV LEGEND
- 96% of cases treated with IA LEGEND
Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Residue Warning: For use only in horses. Do not use in horses intended for human consumption.
Precaution: The safety of LEGEND has not been evaluated in breeding stallions or in breeding, pregnant or lactating mares.