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Research Studies with LEGEND® Injectable solution
(hyaluronate sodium)

Effects of Intravenous Administration of Sodium Hyaluronate on Carpal Joints in Exercise in Horses after Arthroscopic Surgery in Osteochondral Fragmentation.1

Materials and Methods
A study was completed by the Colorado State Equine orthopedic group in twelve clinically sound horses with normal radiographic appearance of their carpal joints. On day 0 each horse had arthroscopic examinations of each carpal joint. One joint in each horse was randomly selected and an osteochondral fragment or bone chip was created with in that joint. Synovial fluid samples were taken on days 0, 13, 20, 27, 34, and 72. Six horses were treated with 40 mg IV LEGEND and six were treated with IV saline on days 13, 20, and 27. Note that the last synovial fluid sample was taken 45 days after the last treatment.

All horses were exercised on a treadmill 5 days a week starting at day 15 which was two days after the first treatment with LEGEND. The study ended on day 72.

Conclusion
Clinical examination, synovial fluid analysis and microscopic examination revealed that the IV administration of LEGEND:

  • Deceased the degree of lameness
  • Decreased the synovial fluid PGE2 levels
  • Decreased synovial fluid protein levels
  • Decreased synovial membrane cellularity
  • Decreased the synovial membrane vascularity

Field Studies with LEGEND (hyaluronate sodium) Injectable Solution2

Field studies were conducted at four different equine veterinary hospitals in the US.

Twenty-one horses were treated with IV LEGEND and twenty-five horses were treated with IA LEGEND. The horses had either carpal or fetlock joint lameness and received 1-3 injections based on clinical improvement.

Overall clinical improvement judged as excellent to good in:

  • 90% of cases treated with IV LEGEND
  • 96% of cases treated with IA LEGEND

Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Residue Warning: For use only in horses. Do not use in horses intended for human consumption.

Precaution: The safety of LEGEND has not been evaluated in breeding stallions or in breeding, pregnant or lactating mares.

IMPORTANT SAFETY INFORMATION:
Click here to view the complete label and usage instructions.

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For use only in horses. Do not use in horses intended for human consumption.

LEGEND 4 mL and LEGEND® Multi dose 20 mL are approved only for I.V. use. LEGEND 2 mL is approved for I.V. and I.A. use. The intra-articular safety of LEGEND Multi Dose with benzyl alcohol has not been evaluated.

The safety of LEGEND has not been evaluated in breeding stallions or in breeding, pregnant or lactating mares.

Not for use in humans. Keep this and all other drugs out of reach of children. Strict aseptic techniques should be observed when administering by intra-articular injection.

Post-Approval Experience: While all adverse reactions are not reported, the following adverse reactions are based on voluntary post-approval reporting for Legend Injectable Solution: Following intravenous use: Occasional depression, lethargy and fever. Following intra-articular (Legend Injectable Solution - 2 mL only) use:lameness, joint effusion, joint or injection site swelling, and joint pain.

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1. Kawcak, CE; Frisbie, DD; Trotter, GW; McIlwraith, CW; Gillette, SM; Powers, BE; Walton, RM: Effects of intravenous administration of sodium hyaluronate on carpal joints in exercising horses after arthroscopic surgery and osteochondral fragmentation. AJVR 1997;58(10):1132-1140.

2. Freedom of Information NADA #140-883